European Society for Evolutionary Biology congress, Groningen, 2017

The European Society for Evolutionary Biology meeting this year took place August 20–25 in Groningen, Netherlands. As usual, the meeting was great, with lots of good talks and posters. I was also happy to meet colleagues, including people from Linköping who I’ve missed a lot since moving.

Here are some of my subjective highlights:

There were several interesting talks in the recombination symposium, spanning from theory to molecular biology and from within-population variation to phylogenetic distances. For example: Irene Tiemann-Boege talked about recombination hotspot evolution from the molecular perspective with mutation bias and GC-biased gene conversion (Arbeithuber & al 2015), while Franciso Úbeda de Torres presented a population genetic model model of recombination hotspots. I would need to pore over the paper to understand what was going on and if the model solves the hotspot paradox (as the title said), and how it is different from his previous model (Úbeda & Wilkins 2011).

There were also talks about young sex chromosomes. Alison Wright talked about recombination suppression on the evolving guppy sex chromosomes (Wright & al 2017), and Bengt Hansson about the autosome–sex chromosome fusion in Sylvioidea birds (Pala & al 2012).

Piter Bijma gave two (!) talks on social genetic effects. That is when your trait value depends not just on your genotype, but on the genotype on others around you, a situation that is probably not at all uncommon. After all, animals often live in groups, and plants have to stay put where they are. One can model this, which leads to a slightly whacky quantitative genetics where heritable variance can be greater than the trait variance, and where the individual and social effects can cancel each other out and prevent response to selection.

I first heard about this at ICQG in Edinburgh a few years ago (if memory serves, it was Bruce Walsh presenting Bijma’s slides?), but have only made a couple of fairly idle and unsuccessful attempts to understand it since. I got the feeling that social genetic effects should have some bearing on debates about kin selection versus multilevel selection, but I’m not sure how it all fits together. It is nice that it comes with a way to estimate effects (given that we know which individuals are in groups together and their relatedness), and there are some compelling case studies (Wade & al 2010). On the other hand, separating social genetic effects from other social effects must be tricky; for example, early social environment effects can look like indirect genetic effects (Canario, Lundeheim & Bijma 2017).

Philipp Gienapp talked about using realised relatedness (i.e. genomic relationships a.k.a. throw all the markers into the model and let partial pooling sort them out) to estimate quantitative genetic parameters in the wild. There is a lot of relevant information in the animal breeding and human genetics literature, but applying these things in the wild comes with challenges that deserves some new research to sort things out. Evolutionary genetics, similar to human genetics, is more interested in parameter estimation than prediction of phenotypes or breeding values. On the other hand, human genetics methods often work on GWAS summary statistics. In this way, evolutionary genetics is probably more similar to breeding. Also, the relatedness structure of the the populations may matter. Evolution happens in all kinds of populations, large and small, structured and well-mixed. Therefore, evolutionary geneticists may work with populations that are different from those in breeding and human genetics.

For example, someone asked about estimating genetic correlations with genomic relationships. There are certainly animal breeding and human genetics papers about realised relatedness and genetic correlation (Jia & Jannik 2012, Visscher & al 2014 etc), because of course, breeders need to deal a lot with correlated traits and human geneticists really like finding genetic correlations between different GWAS traits.

Speaking of population structure, Fst scans are still all the rage. There was a lot of discussion about trying to find regions of the genome that stand out as more differentiated in closely related populations (”genomic islands of speciation/divergence/differentiation”), and as less differentiated in mostly separated populations (introgression, possibly adaptive). But it’s not just Fst outliers. It’s encouraging to see different kinds of quantitative and population genomic methods applied in the same systems. On the hybrid and introgression side of things, Leslie Turner (Turner & Harr 2014) and Jun Kitano (Ravinet & al 2017) gave interesting talks on mice and sticklebacks, respectively. Danièle Filiaut showed an super impressive integrative GWAS and selection mapping study of local adaptation in Swedish Arabidopsis thaliana (Kedaffrec & al 2016).

Susan Johnston spoke about recombination mapping in Soay sheep and Rum deer (Johnston & al 2016, 2017). Given how few large long term genetic studies like this there are, it’s marvelous to be see the same kind of analysis in two parallel systems. Jason Munshi-South gave what seemed like a fascinating talk about rodent evolution in New York City (Harris & Munshi-South 2017). Unfortunately, too many other people thought so too, and I mostly failed to eavesdrop form the corridor.

Finally, Nina Wedell gave a wonderful presidential address about Evolution in the 21th century. ”Because I can. I’m the president now.” Yes!

The talk was about threats to evolutionary biology, examples of it’s usefulness and a series of calls to action. I liked the part about celebrating science much more than the common call to explain science to people. You know, like you hear at seminars and the march for science: We need to ”get out there” (where?) and ”explain what we’re doing” (to whom?). Because if it is true that science and scientists are being questioned, then scientists should speak in a way that works even if they’re not starting by default from a position of authority. Scientists need not just explain the science, but justify why the science is worth listening to in the first place.

”As your current president, I encourage you to celebrate evolution!”

I think this is precisely right, and it made me so happy. Of course, it leaves questions like ”What does that mean?”, ”How do we do it?”, but as a two word slogan, I think it is perfect.

Celebration aligns with sound rhetorical strategy in two ways. First, explanation is fine when someone asks for it, or is otherwise already disposed to listen to an explanation. But otherwise, it is more important to awake interest and a positive state of mind before laying out the facts. (I can’t claim to be any kind of rhetorics expert. But see Rhetoric: for Herennius, Book I, V-VII for ancient wisdom on the topic.) By the way, I’m sure this is what people who are good at science communication actually do. Second, celebration means concentrating on the excitement and wonder, and the good things science can do. In that way, it prevents the trap of listing all the bad things that will happen if Trumpists, creationists and anti-vaccine activists get their way.

Nina Wedell also gave examples of the usefulness of evolution: biomimicry, directed evolution of enzymes, the power of evolutionary algorithms, plant and animal breeding, and prevention of resistance to herbicides and antibiotics. These are all good, worthy things, but also quite a limited subset of evolutionary biology? Maybe this idea is that evolutionary biology should be a basic science supporting applications like these. In line with that, she brought up how serendipitous useful things can come from studying strange diverse organisms and figuring out how they do things. The example in talk was the CRISPR–Cas system. Similar stories apply to a other proteins used as biomedical and biotechnology tools, such as Taq polymerase and Green fluorescent protein.

I have to question a remark about reproducibility, though. The list of threats included ”critique of the scientific method” and concerns over reproducibility, as if this was something that came from outside of science. I may have misunderstood. It was a very brief comment. But if problems with reproducibility are a threat to science, and I think they can be, then it’s not just a problem of image but a problem with how scientists perform, analyse, and report their science.

Evolutionary biology hasn’t been in the reproducibility crisis news the same way as psychology or behavioural genetics, but I don’t know if that is because of better quality, or just that no one has looked that carefully for the problems. There are certainly contradictory results here too, and the same overly flexible data analysis and selective reporting practices that cause problems elsewhere must be common in evolution too. I can think of some reasons why evolutionary biology may be better off. Parts of the field default to analysing data with multilevel or mixed models. Mixed models are not perfect, but they help with some multiple testing problems by fitting and partially pooling a lot of coefficients in the same model. Also, studies that use classical model organisms may be able to get a lot of replication, low variance, and large sample sizes in a way that is impossible for example with human experiments.

So I don’t know if there is a desperate need for large initiatives for replication of key results, preregistration of studies, and improvement of data analysis practice in evolution; there may or there may not. But wouldn’t it still be wonderful if we had them?

Bingo! I don’t have a ton of photos from Groningen, but here is my conference bingo card. Note what conspicuously isn’t filled in: the poster sessions took place in nice big room, and were not that loud. In retrospect, I probably didn’t go to enough of the non-genetic inheritance talks, and I should’ve put Fisher 1930 instead of 1918.

Annonser

See you at #eseb2017

I’m going to Groningen for the European Society for Evolutionary Biology meeting on the 20th to 25th of August.

Given what I’m currently working on, I’m especially excited about the symposium on applications of evolutionary biology in agriculture and industry and also the sprawling three-day genomics of adaptation symposium, but I assume that there will be an abundance of interesting talks and posters all over the place.

If you are there, say hello!

A year ago in Lund: the panel discussion at Evolution in Sweden 2016

This meeting took place on the 13th and 14th of January 2016 in Lund. It feels a bit odd to write about it now, but my blog is clearly in a state of anachronistic anarchy as well as ett upphöjt tillstånd av språklig förvirring, so that’s okay. It was a nice meeting, spanning quite a lot of things, from mosasaurs to retroviruses. It ended with a panel discussion of sorts that made me want to see more panel discussions at meetings.

The panel consisted of Anna-Liisa Laine, Sergey Gavrilets, Per Lundberg, Niklas Wahlberg, and Charlie Cornwallis, and a lot of people joined in with comments. I don’t know how the participants were chosen (Anna-Liisa Laine and Sergey Gavrilets were the invited speakers, so they seem like obvious choices), or how they were briefed; Per Lundberg served as a moderator and asked the other participants about their predictions about the future of the field (if memory serves me right).

I thought some of the points were interesting. One of Sergey Gavrilets’ three anticipated future developments was links between different levels of organisation; he mentioned systems biology and community ecology in the same breath. This sounded interesting to me, who not so secretly dreams of the day when systems biology, quantitative genetics, and populations genetics can all be brought to bear on the same phenotypes. (The other two directions of research he brought up were cliodynamics and human evolution.) He himself had, earlier in his talk, provided an example where a model of human behaviour shows the possibility of something interesting — that a kind of cooperation or drive for equality can be favoured without anything like kin or group selection. That is, in some circumstances it pays to protect the weak, and thus make sure that they bullies do not get too much ahead. He said something to the effect that now is the time to apply evolutionary biology to humans. I would disagree with that. On the one hand, if you are interested in studying humans, any time is the time. On the other hand, if the claim is that now, evolutionary biology is mature and solid, so one can go out and apply it to help other disciplines to sort out their problems … I think that would be overly optimistic.

A lot of the discussion was about Mats Björklund‘s talk about predicting evolution, or failing to do so. Unfortunately, I think he had already left, and this was the one talk of the conference that I missed (due to dull practical circumstances stemming from a misplaced wallet), so this part of the discussion mostly passed me by.

A commonplace that recurred a few times was jokes about sequencing … this or that will not be solved by sequencing thousands of genomes, or by big data — you know the kind. This is true, of course; massively parallel sequencing is good when you want to 1) make a new reference genome sequence; 2) get lots and lots of genetic markers or 3) quantify sequences in some library. That certainly doesn’t cover all of evolutionary biology, but it is still quite useful. Every time this came up part of me felt like putting my hand up to declare that I do in fact think that sequencing thousands of individuals is a good idea. But I didn’t, so I write it here where even fewer people will read it.

This is (according to my notes) what the whiteboard said at the end of the session:

”It’s complicated …”
”We need more data …”
”Predictions are difficult/impossible”
”We need more models”

Business as usual
Eventually we’ll get there (where?)
Revise assumptions, models, theories, methods, what to measure

Nothing in evolutionary biology makes sense except in the light of ecology phylogeny disease

Everything in evolution makes sense in the light of mangled Dobzhansky quotes.

(Seriously, I get why pastiches of this particular quote are so common: It’s a very good turn of phrase, and one can easily substitute the scientific field and the concept one thinks is particularly important. Nothing in behavioural ecology makes sense except in the light of Zahavi’s handicap principle etc. It is a fun internal joke, but at the same time sounds properly authoritative. Michael Lynch’s version sometimes seems to be quoted in the latter way.)

Linköping–Edinburgh–Uppsala

If you are the kind of person who reads the lists of decisions from Formas, you may already know this. In March, I’m starting a new postdoc position, in collaboration with John Hickey’s AlphaGenes group at the Roslin Institute in Edinburgh and Dirk-Jan de Koning’s group at the Swedish University of Agriculture in Uppsala, funded by a mobility starting grant for young researchers from the research council Formas. Hurrah!

The project involves using huge datasets from livestock animals to search for genes and variants underlying quantitative traits. In that sense, for me, this is both a new direction (animal breeding research) and a natural continuation (the genetic basis of quantitative traits). So, in the coming years I anticipate, among other things, learning a ton about computational quantitative genetics; meeting and working with great people; travelling more than ever (relative to my relatively low baseline); writing a poem or two about the scenic environs of Edinburgh and the Royal Mounds of Uppsala; figuring out the across-borders relationship thing; discovering new and useful things about quantitative traits; and hopefully picking up a bit of a Scottish tone in my otherwise Swenglish accent.

Linköping has been very good to me, and so have my colleagues in the Wright lab and AVIAN Behavioural Genetics and Physiology group. So, naturally, I’m both happy and sad to leave. Friends in Linköping, we will meet again.

Also, happy new year!

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(Me holding a sign that says (in Swedish): ”Thank you, Formas! I will do my very best.”)

Some things that happened last year (in pictures and links)

Some things happened in 2015. For one thing, I defended my PhD on the 18th of December. I’m still waiting for some paperwork so I can get a nice diploma, but dear reader, for most intents and purposes, I’m a doctor of genetics! How did that happen? Here is a short chronicle of the year in mobile phone pictures. Enjoy!

In May I went to the conference that is either called the IBANGS meeting or the GBB; I’m not sure which is the proper name, actually. Regardless, it is the meeting of the International Behavior and Neural Genetics Society, and last year it took place in Uppsala. One must take the opportunity when the meeting is in Sweden. I had a poster about some of our work on behavioural genomics under chicken domestication (Johnsson et al. 2016) and also featured on a couple of posters about dog behaviour.

I’ve mostly been to genetics and evolution centric conferences before, so themes and perspectives were a bit new to me. There was quite a bit of neural circuitry and addiction studies, but also a big chunk of genomics-type research. I was surprised by the relative lack of quantitative genetics. I had expected more of that, particularly from the human side. Maybe psychiatric geneticists go to other conferences.

Summer and time to write my dissertation. In fact, since the dissertation was a compilation thesis under the Swedish system, it consisted of a bunch of papers stapled together with a summary (”kappa”, which think comes from the Swedish word for overcoat, not from the Greek letter). Since the papers were either published or quite close to being submitted at this time, most of the writing actually lay behind me. Anyway, I decided to go to some place without distractions for a few days to write. I went to Östersund, where I don’t know anyone, had nothing else to do, and wrote the draft while sitting on cafés and in the candle-lit (!) hotel dining room.

And in August: ESEB! The European Society for Evolutionary Biology meeting took place in Lausanne. That picture with all the greenery, by the way, it’s from the campus!

I gave a talk about our work with the Kauai chicken population (Gering et al. 2015, and unpublished stuff). I remember looking at the list of symposia early in the year and thinking that they looked less interesting than previous years … I don’t remember why, though, and it turns out that I was all wrong, and ended up overwhelmed with talks to go to. As usual, and as it should be. Also: my travel laptop died on me (of course!) and I took this picture with a trash can. Good times.

Speaking of silly selfies: here is me in the chicken house and in the lab. The hammer is the actual RNA isolation hammer; we’ve found that for a lot of frozen tissues, dipping the piece in liquid nitrogen, putting it in a bag and hitting it with a hammer is a good  way to quickly disrupt it before putting it into a homogenizer. The pink tube contains Tri (acid phenol) extraction for RNA isolation. It’s one of the most photogenic steps (one of the few where what’s in the tube isn’t just a colourless liquid).

Winter and time to print and defend the dissertation. Alexander Hultberg made the pretty chicken on the cover. Apparently I took two photos from my defence: one of the opponent, Dirk-Jan de Koning, explaining QTL mapping, and one of his summary slide.

I got a hat. The middle picture shows Dominic Wright giving a speech. I felt very touched.

Finally, Linköping University in winter, and a picture of my sister’s dog, because you know: dog.

I may eventually get back to regular posts about science, or not. In the meantime, here are links to new papers that came out in 2015 (or early 2016) and I had something to do with. Apparently, this was also a year when a lot of stuff went from pipeline into print.

Johnsson M, Williams MJ, Jensen P, Wright D. (2016) Genetical Genomics of Behavior: A novel chicken genomic model for anxiety behavior. Genetics.

Johnsson M, Jonsson KB, Andersson L, Jensen P, Wright D. (2016) Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken. G3.

Fallahsharoudi A, de Kock N, Johnsson M, Ubhayasekera SJ, Bergquist J, Wright D, Jensen P. (2015) Domestication Effects on Stress Induced Steroid Secretion and Adrenal Gene Expression in Chickens. Scientific reports.

Johnsson M, Jonsson KB, Andersson L, Jensen P, Wright D. (2015) Genetic Regulation of Bone Metabolism in the Chicken: Similarities and Differences to Mammalian Systems. PLoS Genetics.

Persson, M. E., Roth, L. S., Johnsson, M., Wright, D., & Jensen, P. (2015). Human‐directed social behaviour in dogs shows significant heritability. Genes, Brain and Behavior.

The paper on the genetics of open field behaviour made the rounds a bit in the media, which was fun. I’m a bit surprised to say that an article in The Daily Mail had the most interesting take … There was also a Nature News feature from collaborators’ field trip to Kauai in the fall, complete with a looping video of my supervisor Dom Wright and collaborator Eben Gering trying to catch a chicken. This is a must-see.

Richard Gray. Forget calling someone a chicken! Farm birds have BRAVERY genes that make them less anxious than their wild cousins The Daily Mail.

Ewen Callaway. When chickens go wild. Nature News.

Last year in Marseille and the EBM18 book

The EBM in Marseille was about a year ago (September 2014), but I don’t mind a bit of blog anachronism. I post this from the European Society for Evolutionary Biology conference in Lausanne. If you happen to be here, you can see me talk about signatures of selection in feralisation in Symposium 20 on Tuesday afternoon.

If you saw a bearded man carrying a pink bag scrambling towards Gare de Marseille Saint-Charles (pictured below; an incredibly beautiful train station) while eating boiled potatoes from a plastic bag, you may have witnessed my stylish departure from Marseille. This was during the Air France strike, and I had just learned that I could catch a train to Nice and go from there. In a moment of brilliance or cheapness, I also decided to spend the night at the airport Nice Côte d’Azur.

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The conference itself was nothing short of wonderful. There were many interesting talks, but it was small enough that everything fit in one track, and there was plenty of time to meet people. The conference also ended with the nicest social activity at any conference I’ve been to: a group of participants went for a walk around Marseille with Pierre Pontarotti and his cute little dog. Myself, I presented our comb size work (2012 paper, 2014 paper and some new stuff). I felt like it went rather well. It seems someone else in the scientific committee thought so too, because I got invited to write a chapter for the book with meeting participants that they make each year. The invitation was to write an overview of the field we talked about, so I wrote about ”The genomics of sexual ornamentation, gene identification and pleiotropy”. One can have a look at the chapter on Google Books. The chapter goes through genomic studies (mostly QTL mapping and gene expression microarrays) on sexual ornaments, and some of the problems and promises.

I am not really sure when the book came out; I saw it popping up on Google Scholar the other day, but I haven’t seen the final version of my chapter. I assume a book is on it’s way or waiting for me when I get back from ESEB.

Pontarotti Pierre (Ed). (2015) Evolutionary Biology: Biodiversification from Genotype to Phenotype. Springer.

Morning coffee: @sweden

This week, I’m tweeting from the @sweden account. It is a rotating account with a new Swede every week. I honestly have no idea who could have nominated me, but I’m flattered and happy. So far I think it’s going well. As I wrote on curatorsofsweden.com:

I’m unlikely to present any great insights about the nature and meaning of Swedishness, but I hope I may be able to give you a new appreciation for the chicken comb.

I think I could probably just keep the week going by answering questions and comments, because there have been many good ones! We’ve been talking about domestication (of course), programming languages for data analysis, the bright but possibly distant future when quantitative genetics and systems biology come together, common misconceptions about genetics, what to say to your creationist friend etc.